Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells as such they are crucial to the healthy functioning of cells recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease from maternally inherited genetic disorders to metabolism defects aging stroke and neurodegenerative diseases such as parkinsons . Mitochondria actively regulate viral infections through modulation of the cellular innate immunity and reprogramming of metabolism in turn hepatitis viruses are able to modulate the morphodynamics and functions of mitochondria but the mode of actions are distinct with respect to different types of hepatitis viruses the resulting mutual interactions between viruses and mitochondria partially explain the clinical presentation of viral hepatitis influence the response to antiviral . Mitochondria in pathogenesis january 10 2017 off science share this mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells as such they are crucial to the healthy functioning of cells recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease from maternally inherited genetic disorders to metabolism . Hepatitis virus mitochondria pathogenesis treatment 1 introduction hepatitis or liver inflammation is one of the most common liver dis eases that imposes a heavy global health burden12 acute hepatitis is either self resolving or develops into chronic hepatitis and subse quently progresses to cirrhosis or hepatocellular carcinoma hcc3 the main etiologies include infection